Researchers from the Oregon Research Institute (ORI) and Florida Atlantic University (FAU) are the first to demonstrate statistically significant links between self-reported regular use of prescription drugs for pain and/or sleep, and longitudinal risk of frailty in adults ages 65 and older.

https://www.technologynetworks.com/drug-discovery/news/regular-use-of-prescription-meds-for-pain-and-sleep-increases-frailty-risk-by-95-327236

https://onlinelibrary.wiley.com/doi/abs/10.1111/jgs.16214