For
several decades now the biomedical research community has pursued a
narrative positing that a combination of ever-deeper knowledge of
subcellular biology, especially genetics, coupled with information
technology will lead to transformative improvements in health care and
human health. In this Viewpoint, we provide evidence for the
extraordinary dominance of this narrative in biomedical funding and
journal publications; discuss several prominent themes embedded in the
narrative to show that this approach has largely failed; and propose a
wholesale reevaluation of the way forward in biomedical research...
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